Web図2 Mincle:脂肪組織の線維化を制御する鍵分子 肥満 脂肪肝 遊離脂肪酸 肝実質細胞 異所性脂肪蓄積 Nat. Commun. 5:e4982. 2014 死細胞に由来する 未知の内因性リガンド? 死細胞 Mincle M1マクロファージ TGF-β など 線維芽細胞 増殖・活性化 線維化 細胞外 ... Macrophage inducible Ca -dependent lectin receptor, (abbreviated to Mincle), is a member of the C-type lectin superfamily encoded by the gene CLEC4E. It is a pattern recognition receptor that can recognize glycolipids including mycobacterial cord factor, trehalose-6,6'-dimycolate (TDM). The mincle receptor binds a range of carbohydrate structures, predominantly containing glucose or mannose, and play an important role in recognition of bacterial glycolipids by the immune system. …
Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation …
Webた.さらに,ヒトMincle-Ig 融合タンパク質を用いて, ヒトMincle とコレステロールが直接結合することを確 認した.これらの結果より,ヒトMincleがコレステロー ル結晶を … WebJul 7, 2024 · The macrophage-inducible C-type lectin (mincle) is part of the innate immune system and acts as a pattern recognition receptor for pathogen-associated molecular patterns (PAMPS) and damage-associated molecular patterns (DAMPs). Ligand binding induces mincle activation which consequently interacts with the signaling adapter Fc … cushman 812916
TREM2 is a receptor for non-glycosylated mycolic acids of
Webexogenous ligand for Mincle, in adipose tissue resulted in adipose tissue fibrosis. These observations sug gest that Mincle activation in obese adipose tissue leads to the progression of adipose tissue fibrosis, t hereby suggesting that Mincle antagonism offers an novel anti-fibrotic therapy for chronic fibrotic diseas es. ¤ ª ì F WebJul 7, 2024 · The macrophage-inducible C-type lectin (mincle) is part of the innate immune system and acts as a pattern recognition receptor for pathogen-associated molecular … WebMincle を発現するマクロファージは、細胞死に陥った近位尿細管(壊 死尿細管)の周囲に集積することが明らかになりました。即ち、Mincle は壊死尿細管を感知して、 腎障害 … cushman 880196